Curcumin and Lung Cancer: the Role of microRNAs.
Curr Pharm Des. 2017;23:1–5
To briefly describe the action of curcumin in regulating the miRNA involved in lung cancer...
Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial.
Inflammopharmacology.2016. DOI: 10.1007/s10787-016-0301-4
To investigate the antioxidant properties of bioavailability-improved preparations of curcuminoids in diabetic patients...
Adjunctive Therapy with Curcumin for Peptic Ulcer: a Randomized Controlled Trial.
Drug Res. 2016;66:1–5
To evaluate the efficacy of Curcumin C3 Complex® as adjunctive therapy on the eradication of H. pylori infection and severity of dyspepsia in patients with PU...
Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial.
Biomed Pharmacother. 2016;82:578–82
To evaluate the effect of supplementation with Curcumin C3 Complex® on concentration of serum cytokines in subjects with MetS...
Effects of supplementation with Curcumin on serum adipokine concentrations: A randomized controlled trial.
Nutrition.2016, DOI: 10.1016/j.nut.2016.03.018
To evaluate changes in serum levels of adiponectin and leptin, and the ratio of these two adipokines, following Curcumin supplementation in patients with MetS....
Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial.
J Diet Suppl. 2016; 13(1):93-105
Exposure to Sulphur Mustard (SM) during Iraq-Iran war (1980-88), not only affected the skin but also caused chronic complications in the respiratory system of civilian and army personnel...
Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial.
J Diet Suppl. 2016; 13(2):209-20
To evaluate the efficacy of Curcumin supplementation in reducing the oxidative stress by measuring the levels of serum concentration of important biomarkers in patients with knee OA...
The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial.
Iran J Pharm Res. 2015; 14(2):479-486.
To investigate the efficacy of curcumin in subjects with coronary artery disease (CAD) by evaluating lipid profile, blood glucose level and inflammatory markers...
Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy.
Cancer Lett. 2015; 364(2):135-41.
To assess the safety, tolerability and feasibility of administering oral Curcumin during standard FOLFOX chemotherapy for palliation of colorectal liver metastases...
Combining curcumin (C3 complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial.
Trials 2015. DOI: 10.1186/s13063-015-0641-1
This randomized, controlled clinical study will be evaluating the effects of CUFOX (Curcumin and FOLFOX) regimen on the colon cancer subjects...
An investigation of the effects of Curcumin on anxiety and depression in obese individuals: A randomized controlled trial.
Chin J Integr Med. 2015; 21(5):332-38
To investigate the antioxidant and anti-inflammatory efficacy of Curcumin on the frequency of symptoms of anxiety and depression in obese individuals...
Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis
Clin Nutr. 2015. DOI: 10.1016/j.clnu.2014.12.019
This study was conducted to understand the effect of curcuminoids on systemic oxidative stress and inflammation by measuring superoxide dismutase activity...
Effect of curcuminoids on oxidative stress:A systematic review and meta-analysis of randomized controlled trials.
J Funct Foods. 2015, DOI: 10.1016/j.jff.2015.01.005
To perform meta-analysis on Curcumin formulations to assess the effect of Curcuminoids supplementation on oxidative stress in health as well as in disease conditions...
Investigation of the Efficacy of Adjunctive Therapy with Bioavailability-Boosted Curcuminoids in Major Depressive Disorder.
Phytother Res. 2015; 29(1):17-21.
Major depressive disorder (MDD) is the most common psychological disorder. The symptoms include irritable mood, disrupted sleep, loss of motivation, decreased concentrating power and even suicidal intentions...
Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial.
Drug Res. 2015; 65(10):521-25
Osteoarthritis (OA) is a degenerative joint disease associated with inflammation. Inflammatory response activates chondrocytes and synoviocytes to produce matrix degrading enzymes...
Short-term Curcuminoid Supplementation for Chronic Pulmonary Complications due to Sulfur Mustard Intoxication: Positive Results of a Randomized Double-blind Placebo-controlled Trial.
Drug Res. 2014. DOI: http://dx.doi.org/10.1055/s-0034-1389986
To investigate effects of Curcuminoids supplementation on markers of pulmonary function and systemic inflammation in SM-intoxicated subjects...
Lipid-modifying effects of adjunctive therapy with curcuminoids–Piperine combination in patients with metabolic syndrome: Results of a randomized controlled trial.
Complement Ther Med. 2014; 22(5):851-57.
To investigate the effects of bioavailability-enhanced Curcuminoids in patients with metabolic syndrome on serum lipid concentration, as an adjunctive to standard of care...
Are Curcuminoids Effective C-Reactive Protein-Lowering Agents in Clinical Practice? Evidence from a Meta-Analysis.
Phytother Res. 2014; 28(5):633-42.
To perform a meta-analysis of clinical trials for investigating the effect of Curcuminoids supplementation on serum CRP concentrations...
Curcuminoid Treatment for Knee Osteoarthritis: A Randomized Double-Blind Placebo-Controlled Trial.
Phytother Res. 2014; 28(11):1625-31.
Osteoarthritis (OA) is the most common disease of joints in adults which leads to stiffness of joints, pain and limitation in joint movement. Treatment of OA is challenging due to inefficacy and long...
Investigation of the effects of Curcumin on serum cytokines in obese individuals: A randomized controlled trial.
Sci World J. 2014. DOI: 10.1155/2014/898361
Obesity is a global health problem and its predisposing effects are atherosclerosis, hypertension, type 2 diabetes, and dyslipidemia...
Topical Curcumin for the Prevention of Oral Mucositis in Pediatric Patients: Case series.
Altern Ther Health Med. 2013; 19(3):21-24.
Oral mucositis (OM), a common consequence of chemotherapy, is caused by inflammation and necrosis of oral mucosa. It has been reported in 40 to 80% of pediatric oncology patients...
Effect of a herbal extract containing Curcumin and Piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers.
Br J Clin Pharmacol. 2013; 75(2):450-62.
Today Curcuminoids have been evaluated for management for several health conditions including Alzheimer’s dementia, cancer and other inflammatory conditions...
Effects of Supplementation with Curcuminoids on Dyslipidemia in Obese Patients: A Randomized Crossover Trial.
Phytother Res. 2013; 27(3):374-9.
Obesity is the major health problem and risk factor for diabetes, dyslipidemia, hyperlipidemia and osteoarthritis...
Curcuminoids modulate pro-oxidant antioxidant balance but not the immune response to heat shock protein 27 and oxidized LDL in obese Individuals.
Phytother Res. 2013; 27(12):1883-8.
Oxidative stress is involved in pathogenesis of atherosclerosis, because of its involvement in oxidation of LDL cholesterol...
Prolonged biologically active colonic tissue levels of Curcumin achieved after oral administration- A clinical pilot study including assessment of patient acceptability.
Cancer Prev Res. 2013; 6(2):119-128.
In previous studies the pharmacokinetic and pharmacodynamics parameters of Curcumin have been reported but few data is available describing whether methodologies are suitably robust for Curcuminoids...
Curcumin for radiation dermatitis: a randomized, double blind, placebo controlled clinical trial of thirty breast cancer patients.
Radiat Res. 2013; 180(1):34-43.
Radiation dermatitis is the common side effect in 95% of patients receiving radiotherapy for sarcoma or various other types of cancer. Skin is susceptible to damage by ionizing radiation because it is a highly proliferative and self-renewing organ...
Long term use of curcumin in two smoldering multiple myeloma patients
J Hematol Malign.2013;3(1):18-23
To study the long term use of Curcumin in two male patients with plasma cell dyscrasias..
Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by Curcumin: results of a randomised, double-blind, placebo-controlled trial.
Br J Nutr. 2012; 108 (7):1272-9.
Sulfur Mustard [Bis (2-chloroethyl) sulphide] or SM has been used as chemical warfare agent for almost 100 years. SM is a compound with potent alkylating, vesicant, blister-forming, cytotoxic, mutagenic and carcinogenic properties...
A randomized controlled trial on the anti-inflammatory effects of Curcumin in patients with chronic sulphur mustard-induced cutaneous complications.
Ann Clin Biochem. 2012; 49(Pt 6):580-88.
To investigate the impact of Curcumin on serum inflammatory biomarkers and their association with pruritus severity and QoL...
To assess the efficacy and safety of NILIN™ SR tablets in the management of osteoarthritis of Knee.
Int J Pharm Life Sci. 2012; 3(2):1413-23.
Osteoarthritis (OA) or degenerative joint disease is one of the oldest and most common types of arthritis, which leads to breakdown of the joint’s cartilage. This results in rubbing of bones against eachother, causing pain and loss of movement...
High dose Curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus.
J Am Acad Dermatol. 2012; 66(5):752-60.
To evaluate the efficacy, safety and tolerability of Curcuminoids at a dose of 6000 mg/day in patients with OLP...
Use of Curcuminoids in a cohort of patients with oral lichen planus, an autoimmune disease.
Phytomedicine 2012; 19(5);418-423.
To summarize long-term open-label use of over the counter (OTC) Curcuminoids i. e. doses,duration and their side effects (including changes in blood count or liver enzymes) in 53 patients with Oral Lichen Planus (OLP) who previously participated in either of the randomized controlled trials of Curcuminoids at UCSF...
Proof of concept of randomized controlled study of Curcumin C3 Complex as adjunct treatment in Schizophrenia: effects on negative and depressive symptoms.
Cultivating Natural Bioactives: International Conference July 9 to 11, 2012.
Authors designed a parallel group randomized trial (15 subjects) of schizophrenia with persisted negative symptomsF...
Oral Curcumin for Alzheimer’s disease: Tolerability and efficacy in a 24 week randomized, double blind, placebo controlled study.
Alzheimers Res Ther. 2012; 4(5):43.
To generate tolerability and preliminary clinical and biomarker efficacy data on Curcumin C3 complex® in persons with mild to moderate AD...
Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and Curcumin: A randomized, double-blind placebocontrolled cross-over 4 g study and an open-label 8 g extension study.
Am J Hematol. 2012; 87(5):455-60.
Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic plasma cell disorders which can progress to multiple myeloma...
Curcumin and EGCG Suppress Apurinic/Apyrimidinic Endonuclease 1 and Induce Complete Remission in B-cell Non-Hodgkin's lymphoma Patientsl.
Funct Food Health Dis. 2011; 1(12):525-44.
To examine the role of human APE1 in resistance and prognosis in FL patients and to evaluate safety and efficacy of combination of curcumin and epigallocatechin gallate (EGCG) therapy in non-Hodgkin follicular lymphoma patients and their peripheral blood mononuclear cells...
A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer.
Cancer Chemother Pharmacol. 2011; 68(1):157-64
To conduct Phase I/II study for determining the safety and feasibility of oral Curcumin in combination with gemcitabine-based chemotherapy in patients with pancreatic cancer...
Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia.
Cancer Prev Res. 2011; 4(3):354-64.
To assess effect of oral administration of Curcumin (a major component of Curcumin C3 complex ®) on PGE2 within ACF, 5-HETE, ACF number and proliferation...
Possible action mechanism for curcumin in pre-cancerous lesions based on serum and salivary markers of oxidative stress.
J Oral Sci. 2010;52(2):251–6.
To test the effect of curcumin in patients with leukoplakia, oral submucous fibrosis and lichen planus by measuring serum and salivary levels of MDA, 8-OHdG and Vitamin C, E before and after curcuminoids administration...
Phase I dose escalation trial of docetaxel plus Curcumin in patients with advanced and metastatic breast cancer.
Cancer Biol Ther. 2010; 9(1):8-14.
To evaluate the role of Curcumin supplementation on breast cancer patients, who were on Docetaxel (100 mg/m2) regimen.In this open-label, Phase I trial, 14 eligible subjects were enrolled who had metastatic...
Curcumin and Gemcitabine in Patients with Advanced Pancreatic Cancer.
Nutr Cancer. 2010; 62(8):1137-41.
To evaluate the activity and feasibility of gemcitabine in combination with Curcumin in patients with advanced pancreatic cancer...
The Potential role of Curcumin in Patients with Monoclonal Gammopathy of Undefined Significance- its Effect on Paraproteinemia and the urinary N-Telopeptide of type I collagen bone turnover marker.
Clin Cancer Res. 2009; 15(18):5917-22.
To determine the effect of Curcumin on plasma cells and osteoclasts in patients with MGUS...
Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer
Clin Cancer Res. 2008; 14(14):4491-9.
To conduct a Phase II study, to determine the biological activity of oral Curcumin in patients with pancreatic cancer...
Oral Curcumin in the treatment of moderate to severe psoriasis vulgaris: A prospective clinical trial.
J Am Acad Dermatol. 2008; 58(4):625-31.
To assess the safety and efficacy of oral Curcumin in the treatment of chronic psoriasis vulgaris..
Curcumin downregulates NF-κB and related genes in patients with multiple myeloma: results of a Phase I/II study.
Blood 2007 110:Abstract1177.
To evaluate the clinical safety and biologic effects of Curcumin in multiple myeloma (MM) patients who had asymptomatic, relapsed/refractory, or plateau phase disease...
A randomized, placebo controlled, double blind clinical trial of Curcuminoids in oral lichen planus.
Phytomedicine 2007; 14 (7-8):437-46.
To evaluate the efficacy and safety of Curcuminoids as an adjunct to short-course corticosteroids for the treatment of patients with OLP...
Combination Treatment With Curcumin and Quercetin of Adenomas in Familial Adenomatous Polyposis.
Clin Gastroenterol Hepatol. 2006; 4:1035–38.
To evaluate the efficacy and toxicity of Curcumin-Quercetin combination to regress intestinal adenomas in subjects suffering from FAP...
Dose escalation of a Curcuminoid formulation.
BMC Complement Altern Med. 2006; 6:10.
To perform a dose escalation study for determining the maximum tolerated dose, safetyprofile, and resultant serum concentration of a single dose of standardized powdered extract (Curcumin C3 Complex ®) obtained from Alleppey finger turmeric...
Consumption of the putative chemopreventive agent Curcumin by cancer patients: Assessment of Curcumin levels in the colorectum and their pharmacodynamics consequences.
Cancer Epidemiol Biomarkers Prev. 2005; 14(1):120-25.
To test the hypothesis that pharmacologically active levels of Curcumin can be achieved in colorectum tissue of humans by oral consumption to effect the levels of M1G and COX-2 proteins...
Phase I Clinical Trial of Oral Curcumin: Biomarkers of Systemic Activity and Compliance.
Clin Cancer Res. 2004; 10(20):6847-54.
To analyze toxicity of high doses of Curcumin administered orally to patients with advanced cancer. To investigate the systemic effects of Curcumin consumption...
Detection of Curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration.
Br J Cancer. 2004; 90(5):1011-5.
To investigate whether oral administration of Curcumin results in concentrations of the agent in normal and malignant liver tissue, which are sufficient to elicit pharmacological activity...
Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers.
Planta Med. 1998; 64(4):353-6.
Curcuminoids, despite showing excellent activity in inhibiting the expression of inflammatory cytokines and inhibition of free radicals, due to its low bioavailability and rapid transformation...